Syntrax Syntrabol Review
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Information about Syntrabol from Derek Cornelius, President of Syntrax
Isoinokosterone, also known as 20-Hydroxyecdysterone, is a polyhydroxylated
sterolic invertebrate growth hormone. The action of this hormone is quite potent
on insects and is actually necessary for their ongoing survival. Because there
is much cross-reactivity and homology in invertebrate and vertebrate hormones,
Doctor Burdette in 1960 began a pioneering work on the effects of ecdysteroids
in vertebrates. As early as 1963, Burdette found that Isoinokosterone enhanced
the rate of protein synthesis in mammalian tissue. This discovery brought many
scientists to the table to study the effects of this interesting hormone. Over
the next 36 years, scientists discovered that Isoinokosterone improves nearly
every bodily function. I will gradually introduce you to this amazing dietary
supplement by first reviewing the relevant research and then describing the
In the early 60’s, Burdette discovered that Isoinokosterone stimulated
protein synthesis but the extent of its stimulatory actions was quite unknown.
In the late 60’s, some forward thinking Japanese scientists by the name of
Okui and Otaki studied the effects of Isoinokosterone on protein synthesis in
male and female mouse liver. In these experiments, the results were compared
against the protein stimulating actions of 4-chlorotestosterone, a potent
anabolic steroid. Amazingly, the time-course of change induced by
Isoinokosterone and 4-chlorotestosterone was similar, with a maximum effect of
200% of controls observed after 5 hours and a return to initial levels after 12
hours. Many similar studies were performed which verified these results
including ones which showed that the protein stimulation occurred in both the
microsomal and polysomal fractions. Other studies in ’69 and ’84 showed that
Isoinokosterone even stimulates protein synthesis in nervous tissue and
increases nerve function. Obviously, the implications of this research are
far-reaching. Could it be possible that Isoinokosterone promotes nerve tissue
healing or even regrowth? Could it be possible that Isoinokosterone restores and
supercharges nervous tissue to work at a maximum level in conjunction with the
other parts of the body?
As positive results were obtained with Isoinokosterone, an increasing amount
of research was performed looking for whole body anabolic effects. In 1969,
another Japanese researcher named Hikino administered Isoinokosterone orally to
mice for a period of 60 days. He found increased growth of the treated mice and
enhanced protein synthesis in the liver and kidney. These results provided more
evidence that Isoinokoste one might produce anabolic effects in vertebrates
including humans. In the 1970’s the former Soviet Union decided to become
involved with the compound as a way to enhance their athletes and still beat
drug tests. Many papers were published on Isoinokosterone in the subsequent
years which convincingly showed its anabolic effects. Most of the experiments
used 5mg per kilogram of body mass per day as the dosage. The effects were
evaluated by measurements of the increased mass, total protein, and glycogen
content of specific muscles (i.e. levator ani and tibialis anterior). As before,
the results were compared against the effects of true vertebrate anabolic
steroids. For instance, a researcher named Chermnykh compared the effects of
Isoinokosterone and Methandrostenolone (a very potent anabolic steroid) in mice
and found some astounding results. These compounds were given to two parallel
experimental sets of mice for seven days—one untrained and the other subjected
to training in the form of repeated swimming. Chermnykh found that both
compounds caused anabolic increases of body mass only under the conditions of
temporary training. Although Isoinokosterone generally stimulated physical
capability for labour, Methandrostenolone could do the same only in association
with temporary training. Methandrostenolone stimulated biosynthesis of the
myofibrilar proteins in the musculus soleus but not in the musculus extensor
digitorum longus, while Isoinokosterone increased the myofibrilar proteins in
both muscles. Similar results have been confirmed in other vertebrate species
consuming Isoinokosterone such as various birds, cattle, pigs, and even humans!
Besides the clear anabolic effects of Isoinokosterone, let us now look at the
myriad of other positive benefits of this incredible compound. Because of the
anabolic similarities between anabolic steroids and Isoinokosterone a researcher
named Yoshida decided to see if there were any other similarities. In 1971 he
studied whether Isoinokosterone would educe the hyperglycemic response to
exogenous glucagons. As expected, Isoinokosterone had a suppressive effect on
hyperglycemia. Interestingly, it did not affect those animals that had normal
blood sugar levels. Furthermore, even though the blood sugar levels were
unaffected in normal animals, it did stimulate the incorporation of glycogen
into proteinaceous tissue such as liver and muscle. The scenario couldn’t be
more ideal! Here we have a compound that will powerfully stabilize your blood
sugar levels and at the same time “feed” your muscles and organs with
energy-giving glycogen. Isoinokosterone is the perfect glycemic regulator. It
will not only prevent you from having high blood sugar levels but also high
insulin levels. High insulin levels stimulate lipogenesis—a process which
basically makes you gain fat mass. With steady and even insulin levels, these
fat-producing processes are halted in their tracks. Even blood sugar levels also
are integral in the feeling of well being for a person as it ensures constant
energy levels. Finally, Isoinokosterone actually pushes nutrients into muscle
and organ tissue allowing for accelerated growth.
Some of you might be saying, “WOW!” right now, but it gets even better.
For instance, Isoinokosterone has a potent cholesterol lowering effect that is
brought on by increasing cholesterol secretion in the bile as well as inhibiting
de novo synthesis of cholesterol. While studying this effect, researches found
that Isoinokosterone produced profound increases in the specific activity of
phosphatidyl-ethanolamine and phosphyatidyl-serine. These phospholipids are
integral to nearly every bodily process and are linked to enormous health
benefits when they are stimulated. A final benefit of Isoinokosterone that was
discovered while studying the cholesterol lowering effect was a potent
hepatoprotective action. This is good news in light of the many potentially
harmful compounds we ingest everyday in our highly processed environment.
The good news hasn’t stopped yet! Isoinokosterone also has beneficial
effects on the cardiovascular system. Because of its cell membrane stabilizing
properties, Isoinokosterone has distinct anti-arrhythmia effects on the heart as
well as a restorative action atherosclerosis. In fact, researchers have
witnessed overall improvements in the hemodynamic conditions of the heart as
well as heart contractility. Continuing along, Isoinokosterone has been also
demonstrated to have analgesic properties as well as potent antioxidative
properties. An important effect of Isoinokosterone for sports enhancement is its
powerful anti-inflammatory properties. Almost too good to be true,
Isoinokosterone has been shown to be as potent as cortisone acetate on specific
inflammatory responses. We thus see Isoinokosterone as an agent that works
against high cortisol levels. How so? Well, glucocorticoids like cortisol are
released in response to stressors such as inflammation. By actively reducing or
eliminating many of these stressors, Isoinokosterone prevents cortisol from
being released from the adrenals. Since glucocorticoids are catabolic to
proteinaceous tissue, it is highly beneficial to do whatever you can to restrict
A final effect that is hinted at in the literature but not fully elucidated
is Isoinokosterone’s effect on the skin. Some research shows a positive effect
on keratinization and differentiation but beyond that—nothing! I have seen,
first hand, its positive effects on acne and believe me it is quite amazing.
Even better is the fact that positive results can be seen within a few days.
Combined with a high quality guggul extract, incredible improvements can be seen
towards blemish-free skin. My guess would be that Isoinokosterone would also be
an effective agent against psoriasis although I have no specific knowledge of it
working therapeutically for this purpose.
One of the greatest things about Isoinokosterone is its utmost safety
profile. Lately, some scoundrels in the industry are gung-ho on calling
everything poisonous and dangerous that they do not distribute (you got it—they
are supplement manufacturers). Unfortunately, they do a ton of damage to this
industry by spreading their false information. Isoinokosterone though is beyond
reproach. You would be hard pressed to find even one small detail that was
negative about Isoinokosterone. In fact, it is so safe that the LD50 in mice is
9grams per kilogram. At this level, an adult male would have to consume nearly
one kilogram of Isoinokosterone to have a good chance of killing you! Since,
Isoinokosterone is recommended at a dosage of 500mg per day, there is basically
zero chance of any problems.
“All of this research is great”, you say, “but what about real world
results?” Some of you might remember that many years ago several companies
were distributing a Suma extract that had Isoinokosterone in it. A whole handful
of pills would only profit you less than 50mg of Isoinokosterone. Not only was
the Isoinokosterone not very bioavailable but the dosage was way too low for
noticeable results. The dilemma with this dietary supplement has always been
obtaining a high potency, pure or semi-pure product that was priced reasonably.
For years, there were only two choices: the ineffective Suma extract and pure
Isoinokosterone from Russia that cost $20,000 per kilogram. Although effective,
it would cost you about $50.00 per day retail to use it in sufficient quantity.
Several years ago, I became very interested in this compound and began looking
into all the possibilities of obtaining a high-potency, economical product.
About a year ago, I started working with an Israeli company on a new process
that would produce Isoinokosterone from an in vitro cell culture system. This
process is extremely high-tech and yields a large amount product at a very cheap
price. Finally, in the 20th century we are able to reap the benefits of this
At this point, real world results are restricted to the trials that the
Russians did on this compound as well as the 20,000 people who have bought the
new, pure version that is now available in the U.S. I communicated with several
Russian researchers who extensively studied this compound on world-class
athletes. Combined, they experimented on about 65 athletes. My staff and I have
also communicated with at least 300 individuals. None of the reports that we
received indicated any negative side effects. Furthermore, nearly every person,
including the Russian scientists, indicated that they noticed significant
increases in lean body mass, endurance, strength and feelings of well-being.
Several experienced bodybuilders that I talked with indicated that they did
better on Isoinokosterone than anything else except high dosages of anabolic
steroids. One runner that I talked to shaved two minutes off his best time!
Finally, a female fitness competitor gained 3 pounds of lean body mass while
becoming significantly leaner.
As you can see, Isoinokosterone is truly a revolutionary supplement. Not only
does it vastly increase athletic performance but it improves nearly every bodily
process. This is very unusual in a compound that does all of this. Usually, like
anabolic steroids, the many positive aspects will be somewhat offset by the few
negative ones. Isoinokosterone, however, powerfully assists you in your goals
while simultaneously improving every aspect of your health. It might not be
magic, but Isoinokosterone is the best “bug juice” I have every seen!
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This information presented is intended to be used for educational purposes only.
The statements made have not been evaluated by the Food and Drug Administration
(U.S.). This stack product is not intended to diagnose, treat, cure or prevent
any condition or disease. Please consult with your own physician or health
care practitioner regarding any suggestions and recommendations made.